This resource may include information that has not been approved by the US Food and Drug Administration. For full prescribing information, including. Fosphenytoin official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Medscape – Epilepsy dosing for Cerebyx (fosphenytoin), frequency-based adverse contraindications, pregnancy & lactation schedules, and cost information. be expressed as phenytoin sodium equivalents (PE) when prescribing; There is.

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Fosphenytoin displaces phenytoin from protein binding sites. Ezetimibe The metabolism of Fosphenytoin can be decreased when combined with Ezetimibe. Flurbiprofen The metabolism of Fosphenytoin can be decreased when combined with Flurbiprofen.

Memantine The metabolism of Fosphenytoin can be decreased when combined with Memantine. Fosphenytpin syndrome may not develop for several days after injection. MK The risk or severity of adverse effects can be increased when Fosphenytoin is combined with MK In addition, advise the patient that these signs and symptoms should be reported even if mild or when occurring after extended use [see Warnings and Precautions 5.

Canakinumab The metabolism of Fosphenytoin can be increased when combined with Canakinumab. Due to an increased fraction of unbound phenytoin in patients with renal or hepatic disease, or in those with hypoalbuminaemia, the interpretation of total phenytoin plasma concentrations should be made with caution as it may not reflect the pharmacologically active unbound concentration.

Hydrocortisone succinate The metabolism of Fosphenytoin can be increased when combined with Hydrocortisone succinate. Monitoring of Patients Continuous monitoring of electrocardiogram, blood pressure and respiratory function for the duration of the infusion is essential. Pro-Epanutin is therefore, contra-indicated in patients with sinus bradycardia, sino-atrial block, second and third degree A-V block and Adams-Stokes syndrome.

Binding to plasma proteins is saturable with the result that the percent bound decreases as infogmation fosphenytoin concentrations increase.

Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Fosphenytoin. Alphacetylmethadol The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Alphacetylmethadol. Date of revision of the text. Fosphenytoin is metabolized to phenytoin, phosphate, and formate.

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Doxofylline The fospjenytoin concentration of Doxofylline can be decreased when it is combined with Fosphenytoin.

Cinitapride The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Cinitapride. Fosphenytoin Sodium Injection and other hydantoins are contraindicated in patients who have experienced prescribinng hypersensitivity [see Contraindications 4 ].

FOSPHENYTOIN SODIUM Injection mg PE in 2ml Vial mg PE in 10 ml Vial | Mylan

Ixabepilone The metabolism of Ixabepilone can be increased when combined with Fosphenytoin. Lorvotuzumab mertansine The metabolism of Fosphenytoin can be decreased when combined with Lorvotuzumab mertansine. Treatment is non-specific since there is no known antidote to Pro-Epanutin or phenytoin overdosage. Chromatographic assay methods e.

Fosphenytoin

Phenytoin hepatic metabolism is saturable and, following administration of single IV Pro-Epanutin doses of to mg PE, total and unbound phenytoin AUC values increase disproportionately with dose. Histamine The metabolism of Fosphenytoin can be decreased when combined with Histamine.

By clicking Subscribe, I agree to the Drugs. Docetaxel The metabolism of Fosphenytoin can be decreased when combined with Docetaxel. Maprotiline Informatkon risk or severity of adverse effects can be increased when Fosphenyroin is combined with Fosphenytoin.

Pro-Epanutin may result in a failure of hormonal contraceptives, hence women of childbearing potential should be counselled regarding the use of other effective contraceptive methods see section 4.

Products with particulate matter or discoloration should not be used. Elvitegravir The metabolism of Fosphenytoin can be decreased when combined with Elvitegravir. Fosphenyton The metabolism of Avanafil can be increased when combined with Fosphenytoin. Drugs that may increase serum phenytoin concentrations listed by likely mechanism: Bromotheophylline The serum concentration of Bromotheophylline can be decreased when it is combined with Fosphenytoin.

Lonidamine The metabolism of Lonidamine can be increased when combined with Fosphenytoin. Mepartricin The metabolism of Fosphenytoin can be decreased when combined with Mepartricin. Ertugliflozin The metabolism of Ertugliflozin can be decreased fosphemytoin combined with Fosphenytoin. Severe cardiovascular reactions including atrial and ventricular conduction depression, ventricular fibrillation, asystole and fatalities have been reported following phenytoin and fosphenytoin administration.

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There are marked variations among individuals with respect to serum phenytoin concentrations where toxicity occurs. Phenytoin is also a potent inducer of hepatic drug-metabolising enzymes and may reduce the levels of drugs metabolized by these enzymes. Kitasamycin The metabolism of Fosphenytoin can be decreased when combined with Kitasamycin.

Continue typing to refine. Miocamycin The metabolism of Fosphenytoin can be decreased when combined with Miocamycin. Bamifylline The serum concentration of Bamifylline can be decreased when it is combined with Fosphenytoin. The same total daily phenytoin sodium equivalents PE dose and dosing frequency prescdibing for oral phenytoin sodium therapy should be administered by IV infusion. Erythromycin The metabolism of Fosphenytoin can be decreased when combined with Erythromycin.

Phenytoin metabolism is slightly decreased in elderly patients. Prescribbing The risk or severity of adverse effects can be increased when Mesoridazine is combined with Fosphenytoin. Following parenteral fosphnytoin of Fosphenytoin Sodium Injection, Fosphenytoin is converted to the anticonvulsant phenytoin.

In contrast, mean maximum unbound phenytoin concentrations increase with both dose and rate. Carboplatin Carboplatin can cause a decrease in the absorption of Fosphenytoin resulting in a reduced serum concentration and potentially a decrease in efficacy. Doxepin The metabolism of Doxepin can be increased when combined with Fosphenytoin. Because this disorder is variable in its expression, other organ systems not noted here may be involved.

Gedocarnil The risk or severity of adverse effects can be increased when Fosphenytoin is fosphenytkin with Gedocarnil. Since fosphenytoin is a prodrug of phenytoin, the carcinogenicity results with phenytoin can be extrapolated.